Etoposide (or VP-16) is another chemotherapy reagent. It is used in
some cases of lymphoma and also in some brain cancers, so it must
cross the blood/brain barrier. I don't know if Hobbes is strong
enough to have chemo anymore, but this may be something you can talk
to your vet about.
I googled Etoposide and came up with alot of information that you may
want to read through.
Kerry
--- In feline_lymphoma@xxxxxxxxxxxxxxx, "kimberlesd" <kimberled@xxxx>
wrote:
>
> Karina,
> I saw a couple of treatments for Hypereosinophilic Syndrome. One
is
> etoposide. The other is Interferon alpha.
> Below is the link to the study on etoposide. It sounds promising.
> It is given by pill. the p[ills seem rather expensive from a quick
> froogle search($6.30) a pill, but the dose is one pill/day for an
> adult human then tapered to 1/2 a day. Much less is needed for
> cats. If there is no other treatment/hope, I would be tempted to
try
> this.
> I 'm sorry you and Hobbes are going through this. It seems to be a
> winter of despair for this group. I hope things get better soon
for
> everyone.
> I am keeping you and Hobbes in my prayers and thoughts.
> Kim
>
> http://www.apfed.org/downloads/Hypereosinophilic%20Syndrome%
202005.pdf
> Oral etoposide (100 mg/d for 10 days, then 50 mg every other day)
was
> added to the steroids. Clinical and biological variables
dramatically
> improved. The prednisone dose was tapered to 0.3 mg/kg per day.
After
> 3 months, the patient was asymptomatic, and his eosinophil counts
> were less than 350 cells/mm3.
> Etoposide (VP16-213) is a podophyllotoxin derivative used in both
> myeloproliferative and lymphoproliferative disorders. A long-term
> response to etoposide has previously been reported in one case of
> steroid-resistant hypereosinophilic syndrome [2]. Because low-dose
> oral etoposide might be efficient in patients with interferon-
> resistant hypereosinophilic syndrome, we suggest that it be tested
as
> a second-line agent in refractory idiopathic hypereosinophilic
> syndrome.
>
>
>
>
>
> --- In feline_lymphoma@xxxxxxxxxxxxxxx, VenusInReverse@xxxx wrote:
> >
> >
> > hi everyone
> >
> >
> > i have been back in touch with Tufts and they have performed the
> lung x-ray,
> > and it revealed everything was normal except for what they
> determine to be a
> > very old problem called "Consolidated Lung".. this basically
means
> that he
> > has an opaque section of lung which was most likely caused by
some
> sort of
> > trauma years ago...
> >
> > they also found that his sternum is at an "abnormal angle" and he
> has two
> > vertebrae which are in an "abnormal position to one another". she
> said this too
> > points to some sort of trauma to the area.
> >
> > the thing that has me most upset about these findings [even
though
> they have
> > little to do with what is causing his present problems] is that
he
> was
> > declawed as a kitten, by his previous owner and it is doubtful
that
> he was ever an
> > outdoor cat, so it is unlikely that the trauma came from
something
> like
> > being hit by a car when he was younger.
> >
> >
> > i can't help but wonder if poor Hobbes wasn't abused by his
> previous owner,
> > or her son.. i remember that the reason the owner gave for giving
> him up
> > [which was posted on his cage at the shelter] as "Owner's son is
> sick", and that
> > never made sense as to why she couldn't keep her cats..
> >
> > now that statement takes on a much more sinister term for me, and
> has had me
> > in tears all afternoon.
> >
> >
> >
> >
> > but aside from all that, the very worse news is that she is
pretty
> sure he
> > has Eosinophilic Leukemia or Hypereosinophilic Syndrome, neither
> of which have
> > treatment or a cure.. i asked if there was another form of chemo
> he could
> > take to help him, but she said no.
> >
> > they have taken him off Leukeran and Prednisone for the time
being,
> which i
> > imagine will just hasten his decline.
> >
> >
> > i really wish he weren't in such a bad state and could at least
get
> the MRI,
> > but as i understand it, that is not an option.
> >
> > they are going to do a repeat Ultrasound tomorrow to see if they
> find any
> > evidence that there was ever lymphoma, but since he has been on
the
> Leukeran and
> > Prednisone for so long, she even doubts if they will be able to
> tell.
> >
> > she said the diagnosis of EL and HS could only be arrived at by
> performing a
> > bone marrow biopsy, but if there is nothing they can do to help
> him, is this
> > even worth putting him through?
> >
> > if there is no cure for what he has, then what hope does he have?
> >
> > this is all so sad, and i am completely broken hearted!
> >
> > please continue to pray for miracles, because every once in a
> while, i still
> > believe they happen.
> >
> > karina and her precious Hobbes.
> >
> >
> >
> >
> >
> > [Non-text portions of this message have been removed]
> >
>
|
